TY  - BOOK
AU  - Kshirsagar,Tushar
TI  - High-throughput lead optimization in drug discovery
T2  - Critical reviews in combinatorial chemistry
SN  - 9781420006964 (ebook : PDF)
PY  - 2008///
CY  - Boca Raton
PB  - CRC Press
KW  - High throughput screening (Drug development)
KW  - Combinatorial chemistry
KW  - Drug development
KW  - Electronic books
KW  - lcsh
N1  - Includes bibliographical references and index; Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee; Also available in print edition; CRC Press (http://www.crcpress.com)
UR  - http://marc.crcnetbase.com/isbn/9781420006964
ER  -