02934cam a2200349Ia 4500 CRC0KE11133PDF BD-DhSAU 20151012144309.0 m|||||o||d|||||||| cr|||| 100602s2011 flu sb 001 0 eng d 9781439825518 (ebook : PDF) BD-DhSAU BD-DhSAU R853.C55 B385 2011 615.50724 B357 Bayesian adaptive methods for clinical trials [electronic resource] / Scott M. Berry ... [et al.]. Boca Raton : Chapman & Hall/CRC, 2011. 323 p. Chapman & Hall/CRC biostatistics series ; 38 Includes bibliographical references and indexes. (Publisher-supplied data) Statistical approaches for clinical trials -- Basics of Bayesian inference -- Phase I studies -- Phase II studies -- Phase III studies -- Special topics. "As has been well-discussed, the explosion of interest in Bayesian methods over the last 10 to 20 years has been the result of the convergence of modern computing power and e�cient Markov chain Monte Carlo (MCMC) algo- rithms for sampling from and summarizing posterior distributions. Prac- titioners trained in traditional, frequentist statistical methods appear to have been drawn to Bayesian approaches for three reasons. One is that Bayesian approaches implemented with the majority of their informative content coming from the current data, and not any external prior informa- tion, typically have good frequentist properties (e.g., low mean squared er- ror in repeated use). Second, these methods as now readily implemented in WinBUGS and other MCMC-driven software packages now oʼer the simplest approach to hierarchical (random eʼects) modeling, as routinely needed in longitudinal, frailty, spatial, time series, and a wide variety of other settings featuring interdependent data. Third, practitioners are attracted by the greater �exibility and adaptivity of the Bayesian approach, which permits stopping for e�cacy, toxicity, and futility, as well as facilitates a straightforward solution to a great many other specialized problems such as dose-nding, adaptive randomization, equivalence testing, and others we shall describe. This book presents the Bayesian adaptive approach to the design and analysis of clinical trials"--Provided by publisher. Also available in print edition. Mode of access: World Wide Web. Clinical trials Statistical methods. Bayesian statistical decision theory. Electronic books. lcsh Berry, Scott M. 9781439825488 Chapman & Hall/CRC biostatistics series ; 38. http://marc.crcnetbase.com/isbn/9781439825518 application/PDF 12122 12121