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008			120329s2012 fluadf sb 001 0 eng d
020			_a9781439825853 (ebook : PDF)
040			_aBD-DhSAU _cBD-DhSAU
090			_aQP363.2 _b.A88 2012
092			_a612.82 _bA859
245	0	0	_aAstrocytes _h[electronic resource] : _bwiring the brain / _ceditors, Eliana Scemes, David C. Spray.
260			_aBoca Raton : _bCRC Press, _c2012.
300			_axix, 397 p., [16] p. of plates : _bill. (some col.).
490	1		_aFrontiers in neuroscience
504			_aIncludes bibliographical references and index.
505	0		_asection 1. Introduction to cluster A : functional biomarkers at the interface -- section 2. Introduction to cluster B : establishment of functional units : multimodality at the tips -- section 3. CNS pathology : disruption of astrocyte connectivity : introduction.
520			_a"Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity.The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. Next, the book examines the role of these connections. It explains how their function can be manipulated under physiological conditions and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain. These include epilepsy, autoimmune encephalitis, Alzheimers disease, autism, and major depression. The book identifies key mechanisms responsible for these alterations.An important and emerging field, astrocytes and their functions are critical to neuroscientists and neurologists, both in academia and in industry, particularly in the search for and development of new drugs to combat a variety of diseases affecting the CNS. As research continues to grow in this area, this volume will spur heightened advances and understanding into the effects of these neural cells on a range of pathologies"--Provided by publisher.
530			_aAlso available in print edition.
538			_aMode of access: World Wide Web.
650		0	_aAstrocytes.
655		7	_aElectronic books. _2lcsh
700	1		_aScemes, Eliana.
700	1		_aSpray, David C.
776	1		_z9781439825846 (hardcover : alk. paper)
830		0	_aFrontiers in neuroscience (Boca Raton, Fla.)
856	4	0	_uhttp://marc.crcnetbase.com/isbn/9781439825853 _qapplication/PDF
999			_c11638 _d11637