| 000 | 02608cam a2200397Ia 4500 | ||
|---|---|---|---|
| 001 | CAH00CE8040PDF | ||
| 003 | BD-DhSAU | ||
| 005 | 20151012144310.0 | ||
| 006 | m|||||o||d|||||||| | ||
| 007 | cr|||| | ||
| 008 | 110928s2011 flu sb 001 0 eng d | ||
| 020 | _a9781584888055 (ebook : PDF) | ||
| 040 |
_aBD-DhSAU _cBD-DhSAU |
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| 090 |
_aRM301.27 _b.R68 2011 |
||
| 092 |
_a615.580724 _bR846 |
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| 100 | 1 | _aRothmann, Mark D. | |
| 245 | 1 | 0 |
_aDesign and analysis of non-inferiority trials _h[electronic resource] / _cMark D. Rothmann, Brian L. Wiens, Ivan S.F. Chan. |
| 260 |
_aBoca Raton, Fla. : _bChapman & Hall/CRC, _c2011. |
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| 300 | _axvi, 438 p. | ||
| 490 | 1 | _aChapman & Hall/CRC biostatistics series | |
| 500 | _a"A Chapman & Hall book." | ||
| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _a1. What is a non-inferiority trial? -- 2. Non-inferiority trial considerations -- 3. Strength of evidence and reproducibility -- 4. Evaluating the active control effect -- 5. Across-trials analysis methods -- 6. Three-arm non-inferiority trials -- 7. Multiple comparisons -- 8. Missing data and analysis sets -- 9. Safety studies -- 10. Additional topics -- 11. Inference on proportions -- 12. Inferences on means and medians -- 13. Inference on time-to-event endpoints. | |
| 520 | _a"The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Using examples from real clinical trials, the book discusses general and regulatory issues and illustrates how they affect analysis. Each chapter begins with a non-technical introduction, so the subject is easily understood by those without prior knowledge of non-inferiority clinical trials. The book also provides detailed mathematical approaches along with their mathematical properties"--Provided by publisher. | ||
| 530 | _aAlso available in print edition. | ||
| 538 | _aMode of access: World Wide Web. | ||
| 650 | 0 |
_aDrugs _xTesting. |
|
| 650 | 0 | _aExperimental design. | |
| 650 | 0 | _aTherapeutics, Experimental. | |
| 655 | 7 |
_aElectronic books. _2lcsh |
|
| 700 | 1 | _aWiens, Brian L. | |
| 700 | 1 | _aChan, Ivan S. F. | |
| 776 | 1 | _z9781584888048 | |
| 830 | 0 | _aChapman & Hall/CRC biostatistics series. | |
| 856 | 4 | 0 |
_uhttp://marc.crcnetbase.com/isbn/9781584888055 _qapplication/PDF |
| 999 |
_c12187 _d12186 |
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