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Adaptive design methods in clinical trials [electronic resource] / authors, Shein-Chung Chow, Mark Chang.

By: Chow, Shein-Chung, 1955-Contributor(s): Chang, MarkMaterial type: TextTextSeries: Chapman & Hall/CRC biostatistics series (Unnumbered)Publication details: Boca Raton : Taylor & Francis, 2012. Edition: 2nd edDescription: xvi, 358 p. : illISBN: 9781439839881 (ebook : PDF)Subject(s): Clinical trials | Adaptive sampling (Statistics) | Experimental design | Clinical trials -- Statistical methodsGenre/Form: Electronic books.Additional physical formats: No titleOnline resources: Click here to access online Also available in print edition.
Contents:
Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.
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Includes bibliographical references and index.

Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.

Also available in print edition.

Mode of access: World Wide Web.

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